Shi Wen-Ying, Li Ping, Chang Xiao-Rong, Lou Bi-Dan, Li Jin-Xiang, Huang Jie, Fan Lei, Luo Rong, Liu Ding, Zhang Wei
The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China.
Zhen Ci Yan Jiu. 2017 Jun 25;42(3):229-34.
To observe the changes of brain rest-state functional connectivity following electroacupuncture (EA) stimulation of right Xia-Jiquan (HT 1), Shaohai (HT 3), Lingdao (HT 4) and Shenmen (HT 7) of the Heart Meridian and non-acupoints in healthy volunteers so as to provide an imaging basis for clinical treatment of some related disorders.
A total of 20 healthy volunteers who met the inclusion criteria were randomly divided into HT-acupoint group (=10 cases) and non-acupoint group (=10 cases) according to the visiting sequence. EA (2 Hz, 2-5 mA) was applied to the right HT 1-HT 3, and HT 4-HT 7 (two outputs of the EA stimulator being connected to two acupuncture needle handles) and non-acupoints (4 spots on the imaginary mid-line between the HT and the Pericardium Meridian apart from the 4 acupoints HT 1-HT 3, and HT 4-HT 7) for 6 min. All the subjects underwent resting-state (rs) fMRI using an Achieva 1.5 T magnetic resonance image (MRI) scanner before and after EA stimulation. The bilateral posterior cingulate was used as the seed point and the functional connectivity data was analyzed by using DPARSF software and rs-fMRI data analysis toolkit.
After EA stimulation of both acupoints and non-acupoints, a similar functional connectivity change was found in the bilateral postcentral gyrus, right inferior parietal lobule, and right inferior frontal gyrus. After EA of acupoints of the HT Meridian, an enhancement of brain functional connectivity was found in the left inferior temporal gyrus and right parahippocampal gyrus, and the newly activated brain regions were the left precentral gyrus, right precuneus, left angular gyrus, left inferior occipital gyrus and the left insula. After EA stimulation of non-acupoints, an increased functional connectivity was found in the left superior temporal gyrus, which was different from EA of acupoints of HT Meridian.
EA stimulation of acupoints of the HT Meridian can enhance the rs functional connectivity in some brain regions as the postcentral gyrus, inferior temporal gyrus, etc. which is related to mediating information of somatosensory, cognitive, affective, memory, cardiovascular activities, etc. in healthy volunteer subjects. The only difference between the two EA groups is an enhanced functional connectivity found in the left superior temporal gyrus after EA of non-acupoints.
观察电针心经右侧侠溪穴（HT 1）、少海穴（HT 3）、灵道穴（HT 4）和神门穴（HT 7）及非穴位后健康志愿者脑静息态功能连接的变化，为临床治疗某些相关疾病提供影像学依据。
将20例符合纳入标准的健康志愿者按就诊顺序随机分为心经穴位组（n = 10例）和非穴位组（n = 10例）。电针（2 Hz，2 - 5 mA）右侧HT 1 - HT 3、HT 4 - HT 7（电针刺激器的两个输出端分别连接两根针灸针柄）及非穴位（心经与心包经之间假想中线处除HT 1 - HT 3、HT 4 - HT 7这4个穴位外的4个点）6分钟。所有受试者在电针刺激前后使用Achieva 1.5 T磁共振成像（MRI）扫描仪进行静息态功能磁共振成像（rs - fMRI）。以双侧后扣带回为种子点，使用DPARSF软件和rs - fMRI数据分析工具包分析功能连接数据。
电针穴位和非穴位后，双侧中央后回、右侧顶下小叶和右侧额下回出现相似的功能连接变化。电针心经穴位后，左侧颞下回和右侧海马旁回脑功能连接增强，新激活的脑区为左侧中央前回、右侧楔前叶、左侧角回、左侧枕下回和左侧岛叶。电针非穴位后，左侧颞上回功能连接增加，这与电针心经穴位不同。
电针心经穴位可增强健康志愿者受试者某些脑区如中央后回、颞下回等的静息态功能连接，这些脑区与体感、认知、情感、记忆、心血管活动等信息的介导有关。两组电针的唯一差异是电针非穴位后左侧颞上回功能连接增强。
