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脊柱肿瘤的立体定向放射外科和放射治疗

Stereotactic radiosurgery and radiation therapy for spinal tumors.

作者信息

Lo Simon S, Chang Eric L, Yamada Yoshiya, Sloan Andrew E, Suh John H, Mendel Ehud

机构信息

Department of Radiation Medicine, Ohio State University Medical Center, Columbus, OH 43210, USA.

出版信息

Expert Rev Neurother. 2007 Jan;7(1):85-93. doi: 10.1586/14737175.7.1.85.

Abstract

Spinal tumors constitute 15% of all CNS neoplasms. Radiation therapy can be administered for palliation of pain and spinal cord compression. However, the amount of radiation that can be administered is often limited by the tolerance of the spinal cord, especially in cases where prior radiation therapy has been given. Stereotactic radiosurgery and radiotherapy allow the delivery of a higher dose of radiation to spinal lesions, while limiting the spinal cord dose to below the tolerance level. These are technically demanding procedures and should be performed only when proper equipment and expertise are available. Data on spinal stereotactic radiosurgery and radiotherapy have emerged in recent years. This review summarizes the clinical applications of stereotactic radiosurgery and radiotherapy for spinal tumors.

摘要

脊柱肿瘤占所有中枢神经系统肿瘤的15%。放射治疗可用于缓解疼痛和脊髓压迫。然而,可给予的放射剂量通常受到脊髓耐受性的限制,尤其是在先前已进行过放射治疗的情况下。立体定向放射外科和放射治疗能够在将脊髓剂量限制在耐受水平以下的同时,向脊柱病变部位给予更高剂量的辐射。这些都是技术要求很高的操作,仅应在具备适当设备和专业知识的情况下进行。近年来已经出现了关于脊柱立体定向放射外科和放射治疗的数据。本综述总结了立体定向放射外科和放射治疗在脊柱肿瘤中的临床应用。

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