• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[Antiviral thiosemicarbazone and related compounds. III. Quantitative relationships between structure and antiviral activity of isantin-beta-isothio-semicarbazone against mengo virus].

作者信息

Franke R, Labes D, Tonew M, Zschiesche W, Heinisch L

出版信息

Acta Biol Med Ger. 1975;34(3):491-9.

PMID:171890
Abstract

The virostatic activity of isatin-beta-isothiosemicarbazones can be described quantitatively by hydrophobic, electronic, and steric substituent constants using multivariate regression analysis. A preceding Free-Wilson analysis allows data smoothening, and thus improved adaptation. Predictions made on the basis of the quantitative structure-action relationships obtained could be confirmed experimentally by synthesizing and testing the corresponding compounds.

摘要

相似文献

1
[Antiviral thiosemicarbazone and related compounds. III. Quantitative relationships between structure and antiviral activity of isantin-beta-isothio-semicarbazone against mengo virus].
Acta Biol Med Ger. 1975;34(3):491-9.
2
[Discriminant-analytic structure-effect relationship of qualitative biological data. Virostatic effect of isatin-beta-isothiosemicarbazones].[定性生物学数据的判别分析结构-效应关系。异吲哚酮-β-异硫代半卡巴腙的抗病毒作用]
Acta Biol Med Ger. 1976;35(1):73-7.
3
[Antiviral isatin-3-thiocarbonylhydrazones and -isothiosemicarbazones and related compounds].
Pharmazie. 1976;31(12):840-5.
4
[Fluorescent antibody method in the study of an antiviral agent: 5-sulfamido--isatin-thiosemicarbazone].[荧光抗体法在一种抗病毒剂研究中的应用：5-磺酰胺基异吲哚啉硫代半卡巴腙]
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1975 Apr-Jun;20(2):113-8.
5
The effect of certain mannich N-bases, derivatives of isatin beta-thiosemicarbazone, on the replication of vaccinia virus in in vitro studies.某些曼尼希N-碱（异硫氰酸苄酯-β-硫代半卡巴腙的衍生物）在体外研究中对痘苗病毒复制的影响。
Acta Microbiol Pol. 1978;27(2):111-21.
6
Inhibition of mengovirus RNA-dependent RNA polymerase by an isatinisothiosemicarbazone and a piperidine-thiocarbonyl-hydrazone derivative in a cell-free system.在无细胞体系中，异吲哚啉硫代半卡巴腙和哌啶-硫代羰基-腙衍生物对脑心肌炎病毒RNA依赖性RNA聚合酶的抑制作用
Virologie. 1980 Apr-Jun;31(2):135-40.
7
Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents.异吲哚酮-β-硫代半卡巴腙作为抗痘病毒药物的组合优化
J Med Chem. 2005 Apr 21;48(8):3045-50. doi: 10.1021/jm049147h.
8
The structure-activity relationships of the antiviral chemotherapeutic activity of isatin beta-thiosemicarbazone.异吲哚酮β-硫代半卡巴腙抗病毒化疗活性的构效关系。
Br J Pharmacol Chemother. 1960 Mar;15(1):101-10. doi: 10.1111/j.1476-5381.1960.tb01216.x.
9
[Effect of izatizon and OL-56 on the reproductive and transformational properties of Marek's disease virus].
Veterinariia. 1977(2):45-6.
10
The effect of isatin beta-thiosemicarbazone derivatives on vaccinia virus multiplication in L-132 cell line (human embryonic lung).异吲哚酮β-硫代半卡巴腙衍生物对痘苗病毒在L-132细胞系（人胚肺）中增殖的影响。
Acta Microbiol Pol A. 1973;5(3):199-204.