Franke R, Meisske W
Acta Biol Med Ger. 1976;35(1):73-7.
"Yes/No" results from the plaque-diffusion inhibition test concerning the virostatic activity of substituted isatin-beta-isothiosemicarbazones against mengo- and vaccinia-viruses can be described discriminant analytically by means of simple substituent constants. The discriminant analysis permits quantitative structure-activity analysis of qualitative and semi-quantitative test data, thus offering a chance for theoretical synthesis optimization already at the level of rough screening.
关于取代异吲哚酮-β-异硫代半卡巴腙对门戈病毒和痘苗病毒的抑制活性，通过噬菌斑扩散抑制试验得到的“是/否”结果可以借助简单的取代基常数进行判别分析。判别分析允许对定性和半定量测试数据进行定量构效分析，从而在初步筛选阶段就为理论合成优化提供了机会。
