脆弱拟杆菌合成一种影响局部和远处区域的DNA转化酶。
Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.
作者信息
Roche-Hakansson Hazeline, Chatzidaki-Livanis Maria, Coyne Michael J, Comstock Laurie E
机构信息
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.
出版信息
J Bacteriol. 2007 Mar;189(5):2119-24. doi: 10.1128/JB.01362-06. Epub 2006 Dec 22.
Abstract
The activity of a fourth conserved tyrosine site-specific recombinase (Tsr) of Bacteroides fragilis was characterized. Its gene, tsr19, is adjacent to mpi, encoding the global DNA invertase regulating capsular polysaccharide biosynthesis. Unlike the other described Tsrs of B. fragilis, Tsr19 brings about inversion of two DNA regions, one local and one located distantly.
摘要
对脆弱拟杆菌的第四个保守酪氨酸位点特异性重组酶（Tsr）的活性进行了表征。其基因tsr19与mpi相邻，mpi编码调节荚膜多糖生物合成的全局DNA转化酶。与其他已描述的脆弱拟杆菌Tsr不同，Tsr19导致两个DNA区域发生倒位，一个是局部区域，另一个是远距离区域。
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