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脆弱拟杆菌合成一种影响局部和远处区域的DNA转化酶。

Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.

作者信息

Roche-Hakansson Hazeline, Chatzidaki-Livanis Maria, Coyne Michael J, Comstock Laurie E

机构信息

Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.

出版信息

J Bacteriol. 2007 Mar;189(5):2119-24. doi: 10.1128/JB.01362-06. Epub 2006 Dec 22.

DOI:10.1128/JB.01362-06
PMID:17189372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1855777/
Abstract

The activity of a fourth conserved tyrosine site-specific recombinase (Tsr) of Bacteroides fragilis was characterized. Its gene, tsr19, is adjacent to mpi, encoding the global DNA invertase regulating capsular polysaccharide biosynthesis. Unlike the other described Tsrs of B. fragilis, Tsr19 brings about inversion of two DNA regions, one local and one located distantly.

摘要

对脆弱拟杆菌的第四个保守酪氨酸位点特异性重组酶（Tsr）的活性进行了表征。其基因tsr19与mpi相邻，mpi编码调节荚膜多糖生物合成的全局DNA转化酶。与其他已描述的脆弱拟杆菌Tsr不同，Tsr19导致两个DNA区域发生倒位，一个是局部区域，另一个是远距离区域。

相似文献

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Bacteroides fragilis synthesizes a DNA invertase affecting both a local and a distant region.脆弱拟杆菌合成一种影响局部和远处区域的DNA转化酶。
J Bacteriol. 2007 Mar;189(5):2119-24. doi: 10.1128/JB.01362-06. Epub 2006 Dec 22.
2
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本文引用的文献

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Extensive DNA inversions in the B. fragilis genome control variable gene expression.脆弱拟杆菌基因组中的广泛DNA倒位控制可变基因表达。
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Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.脆弱拟杆菌的基因组分析揭示了调控细胞表面适应性的广泛DNA倒位。
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14919-24. doi: 10.1073/pnas.0404172101. Epub 2004 Oct 4.
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Tyrosine site-specific recombinases mediate DNA inversions affecting the expression of outer surface proteins of Bacteroides fragilis.酪氨酸位点特异性重组酶介导DNA倒位，影响脆弱拟杆菌外表面蛋白的表达。
Mol Microbiol. 2004 Sep;53(5):1319-30. doi: 10.1111/j.1365-2958.2004.04219.x.
4
Mpi recombinase globally modulates the surface architecture of a human commensal bacterium.Mpi重组酶全面调节一种人体共生细菌的表面结构。
Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10446-51. doi: 10.1073/pnas.1832655100. Epub 2003 Aug 12.
5
Analysis of cepA and other Bacteroides fragilis genes reveals a unique promoter structure.脆弱拟杆菌cepA基因及其他基因的分析揭示了一种独特的启动子结构。
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