Van Guilder Gary P, Hoetzer Greta L, Greiner Jared J, Stauffer Brian L, Desouza Christopher A
Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, 354 UCB, Boulder, CO 80309, USA.
Obesity (Silver Spring). 2006 Dec;14(12):2127-31. doi: 10.1038/oby.2006.248.
Both obesity and the metabolic syndrome (MetS) have been independently linked with increased oxidative and inflammatory stress. This study tested the hypothesis that obesity with MetS is associated with greater oxidative and inflammatory burden compared with obesity alone.
Forty-eight normal-weight and 40 obese (20 without MetS; 20 with MetS) adults were studied. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Plasma concentrations of oxidized low-density lipoprotein, C-reactive protein, tumor necrosis factor-alpha, interleukin (IL)-6, and IL-18 were determined by enzyme immunoassay.
Plasma biomarkers of oxidative stress and inflammation were lowest in normal-weight controls. Of note, obese MetS adults demonstrated significantly higher plasma concentrations of oxidized low-density lipoprotein (62.3 +/- 3.2 vs. 54.0 +/- 4.0 U/L; p < 0.05), C-reactive protein (3.0 +/- 0.6 vs. 1.5 +/- 0.3 mg/L; p < 0.01), tumor necrosis factor-alpha (2.1 +/- 0.1 vs. 1.6 +/- 0.1 pg/mL; p < 0.05), IL-6 (2.8 +/- 0.4 vs. 1.4 +/- 0.2 pg/mL; p < 0.01), and IL-18 (253 +/- 16 vs. 199 +/- 16 pg/mL; p < 0.01), compared with obese adults without MetS.
These results suggest that MetS heightens oxidative stress and inflammatory burden in obese adults. Increased oxidative and inflammatory stress may contribute to the greater risk of coronary heart disease and cerebrovascular disease in obese adults with MetS.
肥胖和代谢综合征（MetS）均与氧化应激和炎症应激增加独立相关。本研究检验了以下假设：与单纯肥胖相比，伴有MetS的肥胖与更高的氧化应激和炎症负担相关。
对48名体重正常的成年人以及40名肥胖成年人（20名无MetS；20名有MetS）进行了研究。MetS根据美国国家胆固醇教育计划成人治疗专家组第三次报告的标准进行定义。采用酶免疫分析法测定氧化型低密度脂蛋白、C反应蛋白、肿瘤坏死因子-α、白细胞介素（IL）-6和IL-18的血浆浓度。
体重正常的对照组中，氧化应激和炎症的血浆生物标志物水平最低。值得注意的是，与无MetS的肥胖成年人相比，伴有MetS的肥胖成年人氧化型低密度脂蛋白（62.3±3.2对54.0±4.0 U/L；p<0.05）、C反应蛋白（3.0±0.6对1.5±0.3 mg/L；p<0.01）、肿瘤坏死因子-α（2.1±0.1对1.6±0.1 pg/mL；p<0.05）、IL-6（2.8±0.4对1.4±0.2 pg/mL；p<0.01）和IL-18（253±16对199±16 pg/mL；p<0.01）的血浆浓度显著更高。
这些结果表明，MetS会加重肥胖成年人的氧化应激和炎症负担。氧化应激和炎症应激增加可能导致伴有MetS的肥胖成年人患冠心病和脑血管疾病的风险更高。
