Kotani Kazuhiko, Satoh Noriko, Kato Yasuhisa, Araki Rika, Koyama Kazunori, Okajima Taiichiro, Tanabe Makito, Oishi Mariko, Yamakage Hajime, Yamada Kazunori, Hattori Masakazu, Shimatsu Akira
Division of Preventive Medicine, Clinical Research Institute for Endocrine Metabolic Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Atherosclerosis. 2009 Jun;204(2):526-31. doi: 10.1016/j.atherosclerosis.2008.09.017. Epub 2008 Sep 27.
The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in relation to the components of the MetS. We also assessed the effect of weight reduction therapy on serum SAA-LDL and AT-LDL levels among obese subjects.
The study population included 421 obese Japanese outpatients (185 men and 236 women, mean age: 51.1 years) enrolled in the multicenter Japan Obesity and Metabolic Syndrome Study (JOMS). The novel oxidized low-density lipoprotein markers, serum SAA-LDL and AT-LDL, were measured in all participants.
Circulating SAA-LDL levels were independently associated with the presence and the number of components of the MetS. SAA-LDL levels were also significantly and independently correlated with high-sensitivity C-reactive protein. Notably, successful weight reduction resulted in a significant decrease in circulating SAA-LDL concentrations. Levels of AT-LDL were not associated with the MetS.
We documented, for the first time, that serum SAA-LDL levels correlate positively with the number of components of the MetS and weight reduction. Whether SAA-LDL may be involved in the pathophysiology of MetS and atherosclerosis deserves further investigation.
新型氧化低密度脂蛋白标志物血清淀粉样蛋白A - 低密度脂蛋白（SAA - LDL）和α1 - 抗胰蛋白酶 - 低密度脂蛋白（AT - LDL）与肥胖及代谢综合征（MetS）之间的假定关联此前尚未得到研究。在本报告中，我们研究了SAA - LDL和AT - LDL水平与MetS各组分的关系。我们还评估了减重治疗对肥胖受试者血清SAA - LDL和AT - LDL水平的影响。
研究人群包括421名参加多中心日本肥胖与代谢综合征研究（JOMS）的肥胖日本门诊患者（185名男性和236名女性，平均年龄：51.1岁）。对所有参与者测量新型氧化低密度脂蛋白标志物血清SAA - LDL和AT - LDL。
循环SAA - LDL水平与MetS的存在及组分数量独立相关。SAA - LDL水平还与高敏C反应蛋白显著且独立相关。值得注意的是，成功减重导致循环SAA - LDL浓度显著降低。AT - LDL水平与MetS无关。
我们首次证明血清SAA - LDL水平与MetS的组分数量及体重减轻呈正相关。SAA - LDL是否参与MetS和动脉粥样硬化的病理生理学值得进一步研究。
