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[长期接受亚硝酸钠和α-生育酚的大鼠的红细胞吞噬作用]

[Erythrophagocytosis in rats long receiving sodium nitrite and alpha-tocopherol].

作者信息

Ivanova A S, Pakhrova O A, Nazarov S B

出版信息

Gig Sanit. 2006 Nov-Dec(6):70-2.

Abstract

The effect of tocopherol in a dose of 150 mg/kg on the activity of erythrophagocytosis was studied in vitro during long-term nitrite intoxication. With sodium nitrite intake, activation of the cellular mechanisms of erythrodieresis was observed in all periods of an experiment, which caused blood cell changes. Administration of tocopherol in the presence of nitrite intoxication was found to reduce the phagocytic activity of macrophages, which prevented the development of anemia.

摘要

在长期亚硝酸盐中毒期间,体外研究了剂量为150mg/kg的生育酚对红细胞吞噬活性的影响。摄入亚硝酸钠后,在实验的所有阶段均观察到红细胞溶解细胞机制的激活,这导致血细胞发生变化。发现在亚硝酸盐中毒情况下给予生育酚可降低巨噬细胞的吞噬活性,从而预防贫血的发生。

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