Ericson H, Blomqvist A, Köhler C
Department of Human Anatomy, University of Uppsala, Sweden.
J Comp Neurol. 1991 Sep 1;311(1):45-64. doi: 10.1002/cne.903110105.
The origin of afferent connections of the hypothalamic tuberomammillary nucleus has been examined by using retrograde and anterograde tracing techniques. Retrogradely labeled neurons were found in about 70 cell groups of the forebrain and brainstem after injection of tracer into the ventral subgroup of the tuberomammillary nucleus. The majority of the labeled neurons were seen in the forebrain, with particularly large numbers in the infralimbic cortex, lateral septal nucleus, and preoptic region. The anterograde tracing experiments supported the general results of the retrograde tracing experiments. However, we did not observe any single cell group that selectively projected to the cell-rich core of the nucleus. In general, only a few fibers entered the core, whereas many labeled fibers seemed to terminate immediately adjacent to the cell group. Thus the target for the afferents is not primarily the perikarya of the neurons of the tuberomammillary nucleus, but either dendrites radiating out from the nucleus or neurons not belonging to the tuberomammillary nucleus. The results of the present study demonstrate that the histaminergic tuberomammillary nucleus derives its main input from the limbic forebrain. Through their widespread projections, the histaminergic neurons may transmit information originating from the limbic system to most if not all parts of the brain.
利用逆行和顺行追踪技术研究了下丘脑结节乳头核传入连接的起源。将示踪剂注入结节乳头核腹侧亚组后，在前脑和脑干的约70个细胞群中发现了逆行标记的神经元。大多数标记神经元见于前脑，在边缘下皮质、外侧隔核和视前区数量尤其多。顺行追踪实验支持了逆行追踪实验的总体结果。然而，我们没有观察到任何选择性投射到该核细胞丰富核心的单一细胞群。一般来说，只有少数纤维进入核心，而许多标记纤维似乎在紧邻细胞群处终止。因此，传入纤维的靶标主要不是结节乳头核神经元的胞体，而是从该核放射出的树突或不属于结节乳头核的神经元。本研究结果表明，组胺能结节乳头核的主要输入来自边缘前脑。通过其广泛的投射，组胺能神经元可能将源自边缘系统的信息传递到大脑的大部分（如果不是全部）区域。
