来自大花百日菊的细胞毒性δ-榄香烯内酯型倍半萜内酯——百日菊内酯A-C

Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora.

作者信息

Bashyal Bharat P, McLaughlin Steven P, Gunatilaka A A Leslie

机构信息

SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA.

出版信息

J Nat Prod. 2006 Dec;69(12):1820-2. doi: 10.1021/np0603626.

DOI:10.1021/np0603626

PMID:17190470

Abstract

Three new delta-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known delta-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.

摘要

通过对大花百日菊地上部分细胞毒性己烷提取物进行生物活性导向分离，分离得到了三种新的δ-榄香烯内酯型倍半萜内酯，即百日菊内酯A - C（1 - 3），以及已知的δ-榄香烯内酯4。1 - 3的结构通过高分辨质谱和核磁共振数据确定。所有化合物对癌细胞系NCI - H460、MCF - 7、SF - 268和MIA Pa Ca - 2以及正常人成纤维细胞系WI - 38均表现出较强的细胞毒性，但均未表现出明显的选择性。