Catania J M, Chen G, Parrish A R
Department of Systems Biology and Translational Medicine, College of Medicine, Texas A&M Health Science Center, College Station, Texas 77843, USA.
Am J Physiol Renal Physiol. 2007 Mar;292(3):F905-11. doi: 10.1152/ajprenal.00421.2006. Epub 2006 Dec 26.
Matrix metalloproteinases (MMPs) are a large family of proteinases that remodel extracellular matrix (ECM) components and cleave a number of cell surface proteins. MMP activity is regulated via a number of mechanisms, including inhibition by tissue inhibitors of metalloproteinases (TIMPs). Originally thought to cleave only ECM proteins, MMP substrates are now known to include signaling molecules (growth factor receptors) and cell adhesion molecules. Recent data suggest a role for MMPs in a number of renal pathophysiologies, both acute and chronic. This review will focus on the expression and localization of MMPs and TIMPs in the kidney, as well as summarizing the current information linking these proteins to acute kidney injury, glomerulosclerosis/tubulointerstitial fibrosis, chronic allograft nephropathy, diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma.
基质金属蛋白酶（MMPs）是一类庞大的蛋白酶家族，可重塑细胞外基质（ECM）成分并裂解多种细胞表面蛋白。MMP活性通过多种机制进行调节，包括金属蛋白酶组织抑制剂（TIMPs）的抑制作用。MMP底物最初被认为仅裂解ECM蛋白，现在已知其包括信号分子（生长因子受体）和细胞粘附分子。最近的数据表明MMPs在多种急性和慢性肾脏病理生理学中发挥作用。本综述将重点关注MMPs和TIMPs在肾脏中的表达和定位，并总结目前将这些蛋白与急性肾损伤、肾小球硬化/肾小管间质纤维化、慢性移植肾肾病、糖尿病肾病、多囊肾病和肾细胞癌相关联的信息。
