Zhou Wei, Fang Jiaxi, Jia Qingqing, Meng Hanyan, Liu Fei, Mao Jianhua
Department of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, China.
Department of Ultrasound, Taizhou Central Hospital, Taizhou, Zhejiang, China.
PeerJ. 2025 Jan 20;13:e18820. doi: 10.7717/peerj.18820. eCollection 2025.
Dysregulated specificity proteins (SPs), members of the C2H2 zinc-finger family, are crucial transcription factors (TFs) with implications for renal physiology and diseases. This comprehensive review focuses on the role of SP family members, particularly SP1 and SP3, in renal physiology and pathology. A detailed analysis of their expression and cellular localization in the healthy human kidney is presented, highlighting their involvement in fatty acid metabolism, electrolyte regulation, and the synthesis of important molecules. The review also delves into the diverse roles of SPs in various renal diseases, including renal ischemia/reperfusion injury, diabetic nephropathy, renal interstitial fibrosis, and lupus nephritis, elucidating their molecular mechanisms and potential as therapeutic targets. The review further discusses pharmacological modulation of SPs and its implications for treatment. Our findings provide a comprehensive understanding of SPs in renal health and disease, offering new avenues for targeted therapeutic interventions and precision medicine in nephrology.
失调的特异性蛋白（SPs）是C2H2锌指家族成员，是对肾脏生理学和疾病有影响的关键转录因子（TFs）。这篇全面的综述聚焦于SP家族成员，尤其是SP1和SP3在肾脏生理学和病理学中的作用。文中详细分析了它们在健康人肾脏中的表达和细胞定位，突出了它们在脂肪酸代谢、电解质调节以及重要分子合成中的作用。该综述还深入探讨了SPs在各种肾脏疾病中的不同作用，包括肾缺血/再灌注损伤、糖尿病肾病、肾间质纤维化和狼疮性肾炎，阐明了它们的分子机制和作为治疗靶点的潜力。综述进一步讨论了SPs的药理学调节及其治疗意义。我们的研究结果为全面理解SPs在肾脏健康和疾病中的作用提供了依据，为肾脏病学中的靶向治疗干预和精准医学提供了新途径。
