从水飞蓟中分离出的（-）-异水飞蓟宾的结构解析及抗氧化活性

Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from Silybum marianum L.

作者信息

Samu Zsuzsanna, Nyiredy Szabolcs, Baitz-Gács Eszter, Varga Zsuzsa, Kurtán Tibor, Dinya Zoltán, Antus Sándor

机构信息

Research Institute for Medicinal Plants, P.O. Box 11, H-2011 Budakalász.

出版信息

Chem Biodivers. 2004 Nov;1(11):1668-77. doi: 10.1002/cbdv.200490125.

DOI:10.1002/cbdv.200490125

PMID:17191807

Abstract

A regioisomer of the known flavanolignan (-)-silandrin (3a), named (-)-isosilandrin (8a), was isolated from the fruits of a white-flowered variant of Silybum marianum L. populated in Hungary. Its structure was established both by spectroscopic methods and total synthesis, and its absolute configuration was determined by means of circular dichroism. This compound showed stronger inhibitory activity on the superoxide anion (O2*-) release by human polymorphonuclear leukocytes (PMNL) than (+)-silybin (1a,b).

摘要

从生长于匈牙利的水飞蓟白色花变种果实中分离出一种已知黄烷木脂素（-）-水飞蓟宾（3a）的区域异构体，命名为（-）-异水飞蓟宾（8a）。通过光谱方法和全合成确定了其结构，并借助圆二色性确定了其绝对构型。该化合物对人多形核白细胞（PMNL）释放超氧阴离子（O2*-）的抑制活性比（+）-水飞蓟素（1a，b）更强。