Microbial transformation of silybin by Trichoderma koningii.
作者信息
Kim Hyun Jung, Park Hae-Suk, Lee Ik-Soo
机构信息
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2006 Feb 15;16(4):790-3. doi: 10.1016/j.bmcl.2005.11.022. Epub 2005 Nov 23.
PMID:16309908
Abstract
Microbial transformation of silybin A (1) and silybin B (2), the major hepatoprotective flavonolignan diastereomers from the fruits of Silybum marianum, with the culture broth of Trichoderma koningii gave two pairs of glucosylated derivatives. Their structures were identified as silybin A 3-O-beta-D-glucopyranoside (3), silybin A 7-O-beta-D-glucopyranoside (4), silybin B 3-O-beta-D-glucopyranoside (5) and silybin B 7-O-beta-D-glucopyranoside (6) by spectroscopic methods.
摘要
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