红曲霉素（一种从毛霉发酵大米提取物（红曲米）中提取的氮杂环类色素）的抗肿瘤起始作用。

Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice).

作者信息

Akihisa Toshihiro, Tokuda Harukuni, Ukiya Motohiko, Kiyota Ayaka, Yasukawa Ken, Sakamoto Naoyuki, Kimura Yumiko, Suzuki Takashi, Takayasu Junko, Nishino Hoyoku

机构信息

College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.

出版信息

Chem Biodivers. 2005 Oct;2(10):1305-9. doi: 10.1002/cbdv.200590101.

DOI:10.1002/cbdv.200590101

PMID:17191930

Abstract

Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.

摘要

红曲素（1）是毛霉发酵大米（红曲米）提取物中的氮杂环庚三烯酮类色素之一。通过口服给药，对化合物1在过氧亚硝酸盐（ONOO⁻；PN）或紫外线B（UVB）作为引发剂、12-O-十四酰佛波醇-13-乙酸酯（TPA）作为促进剂诱导的小鼠皮肤肿瘤两阶段致癌过程中的抗肿瘤启动活性进行了评估。化合物1在PN诱导和UVB诱导的小鼠皮肤致癌试验中均表现出显著的抑制活性。这些发现表明，化合物1作为化学和环境致癌过程中潜在的癌症化学预防剂可能具有重要价值。