（E）-古芸香烯酮的真菌代谢产物及其抗菌和自由基清除活性。

Fungal metabolites of (E)-guggulsterone and their antibacterial and radical-scavenging activities.

作者信息

Choudhary M Iqbal, Shah S Adnan Ali, Sami Amtul, Ajaz Asma, Shaheen Farzana

机构信息

H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

Chem Biodivers. 2005 Apr;2(4):516-24. doi: 10.1002/cbdv.200590033.

DOI:10.1002/cbdv.200590033

PMID:17192001

Abstract

Fungal transformation of (E)-guggulsterone (= (17E)-pregna-4,17-diene-3,16-dione; 1) by Rhizopus stolonifer, Fusarium lini, Cunninghamella elegans, or Gibberella fujikuroi afforded ten hydroxylated metabolites (2-11; Scheme), which were fully characterized. Compounds 4-11 have not been described yet. Some of these novel hydroxylated metabolites, as well as acetylated derivatives thereof, exhibited significant antibacterial and radical-scavenging activities (Table 3).

摘要

匍枝根霉、亚麻镰刀菌、雅致小克银汉霉或藤仓赤霉对（E）-古芸烯酮（=（17E）-孕甾-4,17-二烯-3,16-二酮；1）进行真菌转化，得到了十种羟基化代谢产物（2-11；见方案），并对其进行了全面表征。化合物4-11尚未见报道。其中一些新型羟基化代谢产物及其乙酰化衍生物表现出显著的抗菌和自由基清除活性（表3）。