Shah Syed Adnan Ali, Tan Huey Ling, Sultan Sadia, Faridz Muhammad Afifi Bin Mohd, Shah Mohamad Azlan Bin Mohd, Nurfazilah Sharifah, Hussain Munawar
Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.
Faculty of Chemical Engineering, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor Darul Ehsan, Malaysia.
Int J Mol Sci. 2014 Jul 7;15(7):12027-60. doi: 10.3390/ijms150712027.
Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids.
微生物催化的生物转化在生成种类繁多、结构多样的有机化合物方面具有巨大潜力，尤其是像三萜类化合物这样具有复杂结构的天然产物。它们为生产半合成类似物和新型先导分子提供了高效且经济的方法。细菌和真菌等微生物能够催化各种三萜类底物进行化学、区域和立体选择性羟基化反应，而这些反应通过化学途径极难实现。近年来，针对具有生物活性的三萜类化合物的微生物转化开展了大量研究，旨在获得具有不同结构特征的生物活性分子。本文综述了四环三萜类、四环三萜类和五环三萜类的微生物修饰。
