Total synthesis and biological evaluation of verticipyrone and analogues.
作者信息
Shimamura Hiroyuki, Sunazuka Toshiaki, Izuhara Takashi, Hirose Tomoyasu, Shiomi Kazuro, Omura Satoshi
机构信息
School of Infection Control Sciences and Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
出版信息
Org Lett. 2007 Jan 4;9(1):65-7. doi: 10.1021/ol0626140.
PMID:17192086
Abstract
[reaction: see text] Total synthesis of verticipyrone, a novel NADH-fumarate reductase inhibitor, has been accomplished by a convergent approach using novel "Reverse Julia olefination" method. During total synthetic studies, we also prepared and evaluated several synthetic verticipyrone analogues, some of which exhibited more potent antiparasitic activity than the natural verticipyrone.
摘要
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