纳富雷丁，一种由黑曲霉FT-0554产生的新型NADH-富马酸还原酶抑制剂。

Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.

作者信息

Ui H, Shiomi K, Yamaguchi Y, Masuma R, Nagamitsu T, Takano D, Sunazuka T, Namikoshi M, Omura S

机构信息

Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 2001 Mar;54(3):234-8. doi: 10.7164/antibiotics.54.234.

DOI:10.7164/antibiotics.54.234

PMID:11372780

Abstract

A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-delta-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.

摘要

一种新型化合物萘呋汀，作为厌氧电子传递（NADH-延胡索酸还原酶）的抑制剂被分离出来。它是从一种从海洋海绵中分离得到的黑曲霉FT-0554的培养液中获得的。基于光谱分析，其结构被确认为是一种带有一个连接甲基化烯烃侧链的环氧-δ-内酯。