Liu Ming-Tao, Lin Sheng, Wang Ying-Hong, He Wen-Yi, Li Shuai, Wang Su-Juan, Yang Yong-Chun, Shi Jian-Gong
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, People's Republic of China.
Org Lett. 2007 Jan 4;9(1):129-32. doi: 10.1021/ol062725z.
[structure: see text] Two unusual glycosidic triterpene alkaloids, machilaminosides A (1) and B (2), have been isolated from the stem barks of Machilus yaoshansis. Their structures were elucidated by detailed spectroscopic analysis. A possible biogenetic origin of 1 and 2 mediated by the coupling of 2-O-beta-D-glucopyranosyl-cucurbitacin I, respectively, with urea and adenosine was postulated. 1 and 2 showed nonselective cytotoxic activities against several human cancer cell lines as well as TNF-alpha secretion inhibitory activities.
