Raguckas Sarah E, VandenBussche Heather L, Jacobs Carrie, Klepser Michael E
College of Pharmacy, Ferris State University, Big Rapids, Michigan, USA.
Pharmacotherapy. 2007 Jan;27(1):41-52. doi: 10.1592/phco.27.1.41.
The introduction of routine vaccination against Bordetella pertussis more than a half century ago led to a drastic decline in the number of reported cases of pertussis. It was originally believed that lifelong immunity was afforded after vaccination. Unfortunately, this belief is flawed, as the highest number of pertussis cases since 1959 was reported in 2004. This significant increase has led to additional research on immunity, vaccination, and treatment of B. pertussis in all age groups. We performed a MEDLINE search of literature from 1966-2006 to evaluate and review the existing data on immunity to and prevention or treatment of B. pertussis infections. Additional articles were identified from the bibliographies of reviewed literature. Numerous articles pertaining to these topics have been published recently. The most significant changes in the management of this infectious disease surround the new recommendations by the Advisory Committee on Immunization Practices for adult and adolescent immunizations to assist in preventing outbreaks of B. pertussis. The Centers for Disease Control and Prevention recently published guidelines updating the recommended pharmacologic agents for treatment or prevention of B. pertussis. Despite decades of successful vaccination programs, pertussis continues to be a problematic disease. Fortunately, data and vaccines are now available that make development of a pertussis booster vaccination campaign reasonable. However, until widespread compliance with such programs is achieved, clinicians need to maintain vigilance against pertussis.
半个多世纪前引入的针对百日咳博德特氏菌的常规疫苗接种导致报告的百日咳病例数急剧下降。最初人们认为接种疫苗后可获得终身免疫。不幸的是，这种观点是错误的，因为2004年报告的百日咳病例数是1959年以来最多的。这一显著增加促使人们对所有年龄组百日咳博德特氏菌的免疫、疫苗接种和治疗进行更多研究。我们对1966年至2006年的文献进行了MEDLINE检索，以评估和回顾关于百日咳博德特氏菌感染免疫及预防或治疗的现有数据。从综述文献的参考文献中还识别出了其他文章。最近发表了许多关于这些主题的文章。这种传染病管理方面最显著的变化围绕着免疫实践咨询委员会关于成人和青少年免疫接种的新建议，以帮助预防百日咳博德特氏菌的暴发。疾病控制和预防中心最近发布了指南，更新了用于治疗或预防百日咳博德特氏菌的推荐药物。尽管有几十年成功的疫苗接种计划，但百日咳仍然是一个有问题的疾病。幸运的是，现在已有数据和疫苗，使得开展百日咳加强疫苗接种运动成为合理之举。然而，在实现对此类计划的广泛依从之前，临床医生需要对百日咳保持警惕。
