Vassilopoulos Dimitrios, Mantzoukis Dimosthenis
Academic Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, 115 27 Athens, Greece.
Ann N Y Acad Sci. 2006 Nov;1088:132-8. doi: 10.1196/annals.1366.031.
The crosstalk between the brain and the immune system in inflammatory arthritis is exerted mainly through the activation or downregulation of the hypothalamic-pituitary-adrenal (HPA), the hypothalamic-pituitary-gonadal (HPG), and the hypothalamic-autonomic nervous system (HANS) axes. In this review, we will present an overview of the most recent data regarding the regulation of these complex pathways of neuroendocrine response during the different phases of inflammatory arthritides such as rheumatoid arthritis (RA). Furthermore, the effect of the most recently available biologic therapies like anti-tumor necrosis factor (TNF-a) on the neuroendocrine function in patients with RA will be reviewed.
炎症性关节炎中大脑与免疫系统之间的相互作用主要通过下丘脑 - 垂体 - 肾上腺（HPA）轴、下丘脑 - 垂体 - 性腺（HPG）轴以及下丘脑 - 自主神经系统（HANS）轴的激活或下调来实现。在本综述中，我们将概述关于类风湿关节炎（RA）等炎症性关节炎不同阶段神经内分泌反应这些复杂途径调节的最新数据。此外，还将综述如抗肿瘤坏死因子（TNF - a）等最新可用生物疗法对RA患者神经内分泌功能的影响。
