Otmishi Peyman, Gordon Joshiah, El-Oshar Seraj, Li Huafeng, Guardiola Juan, Saad Mohamed, Proctor Mary, Yu Jerry
Pulmonary and Critical Care, Department of Medicine, Ambulatory Care Building, 3rd floor University of Louisville, Louisville, KY 40292, U.S.A.
Clin Med Circ Respirat Pulm Med. 2008 Apr 29;2:35-44. doi: 10.4137/ccrpm.s547.
The inflammatory response is modulated through interactions among the nervous, endocrine, and immune systems. Intercommunication between immune cells and the autonomic nervous system is a growing area of interest. Spatial and temporal information about inflammatory processes is relayed to the central nervous system (CNS) where neuroimmune modulation serves to control the extent and intensity of the inflammation. Over the past few decades, research has revealed various routes by which the nervous system and the immune system communicate. The CNS regulates the immune system via hormonal and neuronal pathways, including the sympathetic and parasympathetic nerves. The immune system signals the CNS through cytokines that act both centrally and peripherally. This review aims to introduce the concept of neuroimmune interaction and discuss its potential clinical application, in an attempt to broaden the awareness of this rapidly evolving area and open up new avenues that may aid in the treatment of inflammatory diseases.
炎症反应通过神经、内分泌和免疫系统之间的相互作用进行调节。免疫细胞与自主神经系统之间的相互交流是一个日益受到关注的领域。有关炎症过程的空间和时间信息被传递到中枢神经系统（CNS），在那里神经免疫调节有助于控制炎症的程度和强度。在过去几十年中，研究揭示了神经系统和免疫系统进行交流的各种途径。中枢神经系统通过激素和神经元途径调节免疫系统，包括交感神经和副交感神经。免疫系统通过在中枢和外周均起作用的细胞因子向中枢神经系统发出信号。本综述旨在介绍神经免疫相互作用的概念并讨论其潜在的临床应用，试图拓宽对这一快速发展领域的认识，并开辟可能有助于治疗炎症性疾病的新途径。
