神经肌肉接头处的肌肉特异性激酶（MuSK）信号传导
MuSK signaling at the neuromuscular junction.
作者信息
Wang Qiang, Zhang Bin, Xiong Wen-Cheng, Mei Lin
机构信息
Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA, USA.
出版信息
J Mol Neurosci. 2006;30(1-2):223-6. doi: 10.1385/JMN:30:1:223.
The neuromuscular junction (NMJ) is a peripheral cholinergic synapse that conveys signals from motor neurons to muscle cells (Sanes and Lichtman, 1999; Sanes and Lichtman, 2001). The formation of the NMJ requires communication between motoneurons and muscle fibers. Three molecules are essential for NMJ formation: agrin, MuSK, and rapsyn. MuSK appears to be involved in every aspect of NMJ development and maintenance. The paper reviews agrin-MuSK cascades and its potential cross talk with Wnt signaling pathways.
神经肌肉接头（NMJ）是一种外周胆碱能突触，它将信号从运动神经元传递到肌肉细胞（Sanes和Lichtman，1999年；Sanes和Lichtman，2001年）。神经肌肉接头的形成需要运动神经元和肌纤维之间的通讯。有三种分子对神经肌肉接头的形成至关重要：聚集蛋白、肌肉特异性激酶（MuSK）和受体相关蛋白（rapsyn）。MuSK似乎参与了神经肌肉接头发育和维持的各个方面。本文综述了聚集蛋白-MuSK级联反应及其与Wnt信号通路的潜在相互作用。
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