毛大丁草苷：一种从海州常山分离得到的新型抗氧化苯丙素苷。
Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum.
作者信息
Chae Sungwook, Kang Kyoung Ah, Kim Ju Sun, Hyun Jin Won, Kang Sam Sik
机构信息
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
出版信息
Chem Biodivers. 2006 Jan;3(1):41-8. doi: 10.1002/cbdv.200690005.
The structure and antioxidant properties of a new natural glycoside, trichotomoside (1), isolated from Clerodendron trichotomum, were investigated. Trichotomoside was identified as 2-(3-hydroxy-4-methoxyphenyl)ethyl 3-O-(2,3-di-O-acetyl-alpha-L-rhamnopyranosyl)-4-O-[(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside. The compound was active towards intracellular reactive oxygen species (ROS) and exhibited DPPH-radical-scavenging effects. The radical-scavenging activity of 1 was found to protect the viability of Chinese hamster lung fibroblasts (V79-4 cells) exposed to H2O2 and gamma-irradiation.
对从海州常山分离得到的一种新的天然糖苷——三裂叶苷（1）的结构和抗氧化性能进行了研究。三裂叶苷被鉴定为2-(3-羟基-4-甲氧基苯基)乙基 3-O-(2,3-二-O-乙酰基-α-L-鼠李吡喃糖基)-4-O-[(2E)-3-(3-羟基-4-甲氧基苯基)丙-2-烯酰基]-β-D-吡喃葡萄糖苷。该化合物对细胞内活性氧（ROS）具有活性，并表现出DPPH自由基清除作用。发现化合物1的自由基清除活性可保护暴露于H2O2和γ射线的中国仓鼠肺成纤维细胞（V79-4细胞）的活力。
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