来自岩败酱的五种新环烯醚萜类化合物。

Five new iridoids from Patrinia rupestris.

作者信息

Yang Xiu-Ping, Li Er-Wei, Zhang Qi, Yuan Cheng-Shan, Jia Zhong-Jian

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000, PR China.

出版信息

Chem Biodivers. 2006 Jul;3(7):762-70. doi: 10.1002/cbdv.200690078.

DOI:10.1002/cbdv.200690078

PMID:17193308

Abstract

Five new iridoids, namely rupesin A-E (1-5, resp.), together with six known iridoids, 6-11, were isolated from the roots of Patrinia rupestris. Their structures were elucidated by spectroscopic methods including IR, UV, MS, and 1D- and 2D-NMR experiments, and comparison with data of known analogues. Compounds 4 and 11, compounds 1, 2, 5, 6, 8, 9, and 10, and compounds 3, 4, and 8 showed significant antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus, respectively.

摘要

从岩败酱的根部分离出5个新的环烯醚萜类化合物，分别命名为岩败酱素A - E（1 - 5），以及6个已知的环烯醚萜类化合物（6 - 11）。通过红外光谱（IR）、紫外光谱（UV）、质谱（MS）、一维和二维核磁共振（1D - 和2D - NMR）实验等光谱方法，并与已知类似物的数据进行比较，阐明了它们的结构。化合物4和11、化合物1、2、5、6、8、9和10、化合物3、4和8分别对枯草芽孢杆菌、大肠杆菌和金黄色葡萄球菌显示出显著的抗菌活性。