Mathes Wendy Foulds, Kanarek Robin B
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA.
Pharmacol Biochem Behav. 2006 Dec;85(4):762-8. doi: 10.1016/j.pbb.2006.11.011. Epub 2007 Jan 2.
Exercise decreases the antinociceptive effects of opiate drugs. It has been hypothesized that the exercise-induced attenuation of opiate drug action is the result of the development of cross-tolerance between endogenous opioids released during exercise and exogenous opiates. The present study was designed to evaluate the role of exercise on non-opiate antinociception. Female Long-Evans rats were allowed ad lib access to running wheels. After 3 weeks, antinociceptive responses of animals were measured using the tail flick test following the administration of clonidine or nicotine. Nicotine and clonidine both produced dose-dependent increases in antinociceptive responses. Active animals were significantly less sensitive to nicotine-induced antinociception than inactive animals. There was no difference between the two groups in clonidine-induced antinociception. The results of these experiments suggest that exercise does not attenuate non-opioid, clonidine-induced antinociception. However, exercise does attenuate nicotine-induced antinociception. Therefore, the effect of persistent exercise on analgesic drugs is not specific to opiates.
运动可降低阿片类药物的镇痛作用。据推测，运动引起的阿片类药物作用减弱是运动过程中释放的内源性阿片类物质与外源性阿片类药物之间产生交叉耐受的结果。本研究旨在评估运动对非阿片类镇痛作用的影响。给予雌性Long-Evans大鼠自由使用跑步轮的机会。3周后，在给予可乐定或尼古丁后，使用甩尾试验测量动物的镇痛反应。尼古丁和可乐定都能使镇痛反应产生剂量依赖性增加。活跃的动物对尼古丁诱导的镇痛作用的敏感性明显低于不活跃的动物。两组在可乐定诱导的镇痛作用方面没有差异。这些实验结果表明，运动不会减弱非阿片类、可乐定诱导的镇痛作用。然而，运动确实会减弱尼古丁诱导的镇痛作用。因此，持续运动对镇痛药的影响并非阿片类药物所特有。
