Phillips Victoria, McCluggage W Glenn, Young Robert H
Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.
Int J Gynecol Pathol. 2007 Jan;26(1):16-20. doi: 10.1097/01.pgp.0000215303.24653.fc.
We describe an unusual example of ovarian adenomatoid tumor that was an incidental finding in the ovary of a 52-year-old woman and was characterized by cells with abundant eosinophilic cytoplasm, an occasional feature of the adenomatoid tumor but one that, in an ovarian example, may cause added diagnostic confusion to that already engendered by the rarity of this neoplasm in the ovary. The typical numerous small vacuoles of the neoplasm sometimes had the appearance of signet ring cells. These 2 features (oxyphil and signet ring cells) caused a broad differential. Tumor cells were positive with broad-spectrum cytokeratins as well as mesothelial markers CK5/6, WT1, and calretinin. In reporting this case, we focus on the differential diagnosis of ovarian neoplasms and tumorlike conditions with vacuoles and related spaces, a topic that embraces many diverse entities.
我们描述了一例不寻常的卵巢腺瘤样瘤，这是在一名52岁女性卵巢中偶然发现的，其特征是细胞具有丰富的嗜酸性细胞质，这是腺瘤样瘤偶尔出现的特征，但在卵巢病例中，这一特征可能会给本就因该肿瘤在卵巢中罕见而产生的诊断带来更多困惑。肿瘤典型的众多小空泡有时呈现印戒样细胞外观。这两个特征（嗜酸性细胞和印戒样细胞）导致了广泛的鉴别诊断。肿瘤细胞对广谱细胞角蛋白以及间皮标记物CK5/6、WT1和钙视网膜蛋白呈阳性反应。在报告该病例时，我们重点关注具有空泡和相关间隙的卵巢肿瘤及肿瘤样病变的鉴别诊断，这一主题涵盖了许多不同的实体。
