Hayati Abdul Rahman, Zulkarnaen Mohammad
Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Int J Gynecol Pathol. 2007 Jan;26(1):83-8. doi: 10.1097/01.pgp.0000225850.90115.bc.
Cervical carcinoma is the second leading cancer in women in Malaysia, after breast cancer. Human papillomavirus (HPV) has been implicated in the development of dysplasia or cervical intraepithelial neoplasia and progression to squamous cell carcinoma. Because of the confinement of the human papillomavirus infection within the epithelial layer, the presence of dentritic cells or Langerhans cells in epithelial layer of the ectocervix is paramount in producing immune response. The mature dentritic cells express CD83 and high CD40/80/86, whereas the immature cells express CD1a and low CD40/80/86. By identifying CD1a and CD83, theoretically, both immature and mature dentritic cell populations can be studied. In view of the facts, we investigated the infiltrating cell density of mature and immature dentritic cells in cervical neoplasia.
宫颈癌是马来西亚女性中仅次于乳腺癌的第二大常见癌症。人乳头瘤病毒（HPV）与发育异常或宫颈上皮内瘤变以及进展为鳞状细胞癌有关。由于人乳头瘤病毒感染局限于上皮层内，因此宫颈外口上皮层中树突状细胞或朗格汉斯细胞的存在对于产生免疫反应至关重要。成熟的树突状细胞表达CD83以及高表达CD40/80/86，而未成熟细胞表达CD1a以及低表达CD40/80/86。从理论上讲，通过识别CD1a和CD83，可以研究未成熟和成熟的树突状细胞群体。鉴于这些事实，我们研究了宫颈肿瘤中成熟和未成熟树突状细胞的浸润细胞密度。
