巴西中枢神经系统的病毒感染

Viral infections of the central nervous system in Brazil.

作者信息

Mendoza Laura Patricia, Bronzoni Roberta Vieira de Morais, Takayanagui Osvaldo Massaiti, Aquino Victor Hugo, Figueiredo Luiz Tadeu Moraes

机构信息

Virus Research Unit, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, 14049-000 Ribeirão Preto, SP, Brazil.

出版信息

J Infect. 2007 Jun;54(6):589-96. doi: 10.1016/j.jinf.2006.11.013. Epub 2007 Jan 2.

DOI:10.1016/j.jinf.2006.11.013

PMID:17198733

Abstract

OBJECTIVE

Epidemiological studies have shown that most central nervous system (CNS) infections are viral. The objective of this study is to contribute to the knowledge base concerning viral CNS infections in Ribeirão Preto, Brazil.

METHODS

Two hundred cerebrospinal fluid (CSF) samples were taken from patients with clinically suspected viral CNS infection and analyzed for herpesvirus, enterovirus, alphavirus and flavivirus using PCR assays.

RESULTS

Viral genome was detected in 43 CSF samples (23.34%): 6% cytomegalovirus (CMV), 5% herpes simplex virus type 1 (HSV-1), 0.5% each varicella-zoster virus (VZV) and Epstein-Barr virus (EBV), and 11.34% enterovirus. Co-infections (CMV-enterovirus and CMV-HSV-1) were found in 3 patients. CSF parameters such as cytology and protein level were normal in many patients with viral genome-positive CSF.

CONCLUSIONS

Data obtained in this study contribute to the knowledge base concerning viral CNS infections in Brazil. This information will have a major impact on the clinical management of patients with CNS disease.

摘要

目的

流行病学研究表明，大多数中枢神经系统（CNS）感染是由病毒引起的。本研究的目的是为巴西里贝朗普雷图地区病毒所致中枢神经系统感染的知识库提供资料。

方法

从临床上怀疑有病毒所致中枢神经系统感染的患者中采集200份脑脊液（CSF）样本，采用聚合酶链反应（PCR）检测分析其中的疱疹病毒、肠道病毒、甲病毒和黄病毒。

结果

在43份脑脊液样本（23.34%）中检测到病毒基因组：6%为巨细胞病毒（CMV），5%为1型单纯疱疹病毒（HSV-1），水痘带状疱疹病毒（VZV）和爱泼斯坦-巴尔病毒（EBV）各占0.5%，11.34%为肠道病毒。3例患者存在合并感染（CMV-肠道病毒和CMV-HSV-1）。许多脑脊液病毒基因组呈阳性的患者，其脑脊液细胞学和蛋白水平等参数正常。