Kim Seog Ju, Jeong Do-Un, Sim Minyoung E, Bae Soojeong C, Chung Ain, Kim Minue J, Chang Kee Hyun, Ryu Jeong, Renshaw Perry F, Lyoo In Kyoon
Department of Psychiatry, Gachon University of Medicine and Science, Incheon, South Korea.
Neuropsychobiology. 2006;54(2):120-5. doi: 10.1159/000098262. Epub 2007 Jan 3.
Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder (PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD.
此前，我们团队在全脑探索中报告了创伤后应激障碍（PTSD）患者左侧前扣带回白质纤维束完整性的改变。当前研究旨在探究这种改变在扣带束的任何特定区域是否更为显著。采集了21名PTSD患者和21名健康对照者的扩散张量图像。选取了八个等立方感兴趣区域（ROI），即双侧喙部、膝下、背侧和上扣带束。测量并比较了两组中每个ROI的分数各向异性值，该值指示白质纤维束的完整性。相对于对照者，PTSD患者在喙部、膝下和背侧扣带束左侧的分数各向异性值显著更小（分别降低了26.7%、25.0%、22.2%），但右侧ROI未出现这种情况。我们报告了PTSD患者扣带束的不对称改变。
