Matyska-Piekarska Ewa, Łuszczewski Adam, Łacki Jan, Wawer Iwona
Klinika Chorób Reumatycznych, Instytut Reumatologii w Warszawie.
Postepy Hig Med Dosw (Online). 2006;60:617-23.
Numerous scientific investigations confirmed the occurrence of oxidative stress in rheumatoid arthritis patients. There is evidence demonstrating elevated levels of oxidative stress markers and oxidative damage caused by reactive oxygen species (ROS) to lipids, proteins, sugars, and DNA, as well as a significant decrease in total antioxidant capacity, which protects the organism against ROS activity. Extensive ROS production can significantly accelerate the process of articular cartilage damage. It is believed that many disease-modifying anti-rheumatic drugs (DMARDs) affect oxidative stress, although there has been insufficient research to confirm such a relationship.
众多科学研究证实类风湿关节炎患者体内存在氧化应激现象。有证据表明，氧化应激标志物水平升高，活性氧（ROS）对脂质、蛋白质、糖类和DNA造成氧化损伤，同时总抗氧化能力显著下降，而总抗氧化能力可保护机体免受ROS活性影响。大量ROS生成会显著加速关节软骨损伤进程。尽管目前尚无足够研究证实这种关系，但人们认为许多改善病情抗风湿药（DMARDs）会影响氧化应激。
