Petrov S V, Raĭkhlin N T, Serre G
Arkh Patol. 1991;53(6):7-11.
25 skin basaliomas were studied immunohistochemically using 6 different monoclonal antibodies (MAB) to the low-molecular cytokeratins N 8, 18 (according to Moll's catalog) as well as to the cytokeratins N 1, 2, 9, 10, 11 and N 17. Prekeratin N 17 was found in all tumours while cytokeratin N 18 was found in no tumour. Prekeratin N 8 was expressed in 24% of tumours. MAB EE 21-06 to the cytokeratin N 1, 2, 9, 10, 11 are reactive with tumour cells in 20% of cases. Basalioma cells (apart from trichobasalioma) did not react with MAB G 36-19. These results suggest a dissimilar origin of basaliomas and may help in the differential diagnosis of the skin malignant tumours.
使用6种不同的针对低分子量细胞角蛋白N 8、18（根据莫尔分类法）以及细胞角蛋白N 1、2、9、10、11和N 17的单克隆抗体（MAB），对25例皮肤基底细胞瘤进行了免疫组织化学研究。在所有肿瘤中均发现前角蛋白N 17，而在任何肿瘤中均未发现细胞角蛋白N 18。前角蛋白N 8在24%的肿瘤中表达。针对细胞角蛋白N 1、2、9、10、11的MAB EE 21 - 06在20%的病例中与肿瘤细胞发生反应。基底细胞瘤细胞（除毛发基底细胞瘤外）不与MAB G 36 - 19发生反应。这些结果提示基底细胞瘤起源不同，可能有助于皮肤恶性肿瘤的鉴别诊断。
