Pantos C, Mourouzis I, Paizis I, Malliopoulou V, Xinaris Ch, Moraitis P, Cokkinos A D, Cokkinos D V
Diabetes Obes Metab. 2007 Jan;9(1):136-8. doi: 10.1111/j.1463-1326.2006.00587.x.
It has been previously reported that thyroid hormone receptor alpha1 (TRalpha1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRalpha1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRalpha1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.
先前已有报道称，甲状腺激素受体α1（TRα1）参与食物摄入和心律的调节。在此，我们表明，决奈达隆（一种类似胺碘酮的化合物，已证明可拮抗甲状腺激素与TRα1的结合）对TRα1的药理抑制作用，可防止甲状腺激素诱导的大鼠食物摄入量增加和心率加快。这导致体重显著下降。甲状腺类似物可能被证明是控制体重的潜在治疗药物。
