El-Abbadi Mohga, Giachelli Cecilia M
Department of Bioengineering, University of Washington, Seattle 98195, WA. USA.
Adv Chronic Kidney Dis. 2007 Jan;14(1):54-66. doi: 10.1053/j.ackd.2006.10.007.
Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important contributory factors for vascular calcification in these patients. This article reviews current mechanisms proposed for the regulation of vascular calcification and data supporting their potential contribution to this process in chronic kidney disease.
血管钙化在慢性肾脏病患者中非常普遍，且与心血管高死亡率相关。最近的证据表明，促进血管细胞表型改变的矿物质、激素和代谢失衡，以及特定矿化抑制途径的缺陷，可能是这些患者血管钙化的重要促成因素。本文综述了目前提出的血管钙化调节机制，以及支持其在慢性肾脏病中对这一过程潜在作用的数据。
