Department of Radiology, The First Affiliated Hospital of The University of South China, Hengyang, Hunan, China.
Changsha Central Hospital Affiliated to University of South China, Changsha, Hunan, China.
Mol Biol Rep. 2024 May 6;51(1):622. doi: 10.1007/s11033-024-09550-1.
Menopause is a normal physiological process accompanied by changes in various physiological states. The incidence of vascular calcification (VC) increases each year after menopause and is closely related to osteoporosis (OP). Although many studies have investigated the links between VC and OP, the interaction mechanism of the two under conditions of estrogen loss remains unclear. MicroRNAs (miRNAs), which are involved in epigenetic modification, play a critical role in estrogen-mediated mineralization. In the past several decades, miRNAs have been identified as biomarkers or therapeutic targets in diseases. Thus, we hypothesize that these small molecules can provide new diagnostic and therapeutic approaches. In this review, we summarize the close interactions between VC and OP and the role of miRNAs in their interplay.
绝经是一个伴随各种生理状态变化的正常生理过程。绝经后，血管钙化（VC）的发生率逐年增加，与骨质疏松症（OP）密切相关。虽然许多研究已经探讨了 VC 和 OP 之间的联系，但在雌激素缺乏的情况下，两者之间的相互作用机制尚不清楚。微小 RNA（miRNA）参与表观遗传修饰，在雌激素介导的矿化中发挥关键作用。在过去的几十年中，miRNA 已被确定为疾病的生物标志物或治疗靶点。因此，我们假设这些小分子可以提供新的诊断和治疗方法。在这篇综述中，我们总结了 VC 和 OP 之间的密切相互作用以及 miRNA 在它们相互作用中的作用。
