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Past-users of HRT are osteopenic four months after discontinuation:an observational and cross-sectional study.

作者信息

Aubertin-Leheudre Mylène, Mèlançon Michel O, Chaput Jean-Philippe, Dionne Isabelle J

机构信息

Research Centre on Aging, Faculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, Québec, Canada.

出版信息

J Women Aging. 2006;18(4):19-29. doi: 10.1300/J074v18n04_03.

DOI:10.1300/J074v18n04_03
PMID:17200061
Abstract

Hormonal replacement therapy (HRT) helps to prevent osteoporosis. The effect of short-term discontinuation of a long-term HRT on bone mineral density (BMD) in healthy post-menopausal women is unknown. Fifteen women on HRT (HRT users), 17 who never used HRT (non-users) and 8 former HRT users (past-HRT users) were recruited. BMD was measured by DXA. Our results allow to hypothesize that BMD may decline after short-term HRT discontinuation, which would increase the fracture risks. Indeed, our results show that past-HRT users are osteopenic just as non-users. However, these results should be re-examined using a prospective trial and a larger sample size.

摘要

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