Morozowich Steven T, Donahue Brian S, Welsby Ian J
Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Semin Cardiothorac Vasc Anesth. 2006 Dec;10(4):297-313. doi: 10.1177/1089253206294345.
Genetic variants in the coagulation system have been known since antiquity. Today, because of modern improvements in diagnosis and medical management, the clinician is likely to encounter a spectrum of coagulation factor deficiencies and identified polymorphic variants in the surgical population. Because perioperative hemorrhagic and thrombotic complications are potentially serious, it is important to understand the role that these defects and variants may play in predicting risk and optimizing patient management. The implications of coagulation genetics on the perioperative management of the cardiac surgery patient are reviewed.
凝血系统中的基因变异自古以来就为人所知。如今，由于诊断和医疗管理方面的现代进步，临床医生在外科手术人群中可能会遇到一系列凝血因子缺乏症以及已确定的多态性变异。由于围手术期出血和血栓形成并发症可能很严重，了解这些缺陷和变异在预测风险和优化患者管理中可能发挥的作用非常重要。本文综述了凝血遗传学对心脏手术患者围手术期管理的影响。
