Kfoury Elias, Taher Ali, Saghieh Said, Otrock Zaher K, Mahfouz Rami
Department of Surgery, American University of Beirut Medical School, Beirut, Lebanon.
Mol Biol Rep. 2009 May;36(5):1041-51. doi: 10.1007/s11033-008-9278-4. Epub 2008 May 31.
This article mainly reviews hypercoagulability--and specifically inherited thrombophilia--in different types of surgery including kidney transplantation, simultaneous kidney and pancreas transplantation, orthopedic surgery, vascular surgery, cardiac surgery and other categories of surgical procedures, with a major focus on its associated complications and the need to screen or not. A search was conducted using Medline and cross-referencing for articles related to thrombophilia, screening for it, and its association with surgical complications post-op. Thrombosis associated predisposing entities like factor V Leiden, Prothrombin and Methylene tetrahydrofolate reductase gene mutations, in addition to Protein C and S deficiencies, are discussed. In addition, common and relatively uncommon complications of thrombophilia in the above mentioned surgeries will be covered in length, as well as the necessity to screen for thrombophilia prior to the surgical step. This topic is gaining more and more importance for both surgeons and internists (especially Hematologists) and we, herein, present a general review of the published literature as an update on the subject.
本文主要回顾了不同类型手术中的高凝状态，特别是遗传性易栓症，这些手术包括肾移植、肾胰联合移植、骨科手术、血管手术、心脏手术及其他各类外科手术，重点关注其相关并发症以及是否需要进行筛查。我们使用Medline进行检索，并交叉引用了与易栓症、易栓症筛查及其与术后手术并发症关联的文章。文中讨论了与血栓形成相关的易感因素，如凝血因子V莱顿突变、凝血酶原和亚甲基四氢叶酸还原酶基因突变，以及蛋白C和S缺乏症。此外，还将详细介绍上述手术中易栓症的常见和相对罕见的并发症，以及手术前筛查易栓症的必要性。这一主题对外科医生和内科医生（尤其是血液科医生）越来越重要，在此，我们对已发表的文献进行全面综述，作为该主题的最新资料。
