Esmaeili A, Schlatterer K, Demirhan I, Schlatterer B, Nauck M, Chandra P, Chandra A
Department of Pediatric Cardiology, Johann Wolfgang Goethe University Hospital, 60590 Frankfurt am Main, Germany.
Anticancer Res. 2006 Nov-Dec;26(6B):4203-12.
The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic effect was studied.
采用宿主介导的体外/体内分析系统评估芳香族硝基化合物2-硝基苯甲醚（2-NA）的致瘤潜力。腹腔注射该化合物后，通过腹腔灌洗从处理过和未处理的小鼠中回收常驻巨噬细胞，并在软琼脂中培养。结果表明2-NA具有致癌性，并对其致瘤潜力进行了评估。此外，通过建立转化的腹膜巨噬细胞系，研究了2-NA致癌作用的潜在分子机制。
