Acta Chim Slov. 2021 Jun;68(2):488-493.
For thyroid function estimation and clinical decision making, use of appropriate reference intervals for thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) is crucial. For each laboratory, establishment of own reference intervals is advised. For the first Slovenian estimation of reference intervals for thyroid hormones a large group of 1722 healthy individuals without thyroid disease was established retrospectively. Hormone analyses were performed on automated analyser Advia Centaur XP Immunoassay System (Siemens Healthineers), which reference intervals for TSH, fT4 and fT3 were 0.55-4.78 mIU/L, 11.5-22.7 pmol/L, and 3.5-6.5 pmol/L, respectively. Statistical analysis followed non-parametric percentile method. Our laboratory reference intervals for TSH, fT4 and fT3 are mostly narrower than intervals given by manufacturer. Median value, lower and upper limit for TSH, fT4 and fT3 were 1.98 (0.59-4.23) mIU/L, 14.5 (11.3-18.8) pmol/L and 4.82 (3.79-6.05) pmol/L, respectively. Most likely, an inclusion of a high number of healthy individuals without thyroid disease was a reason for such results.
为了进行甲状腺功能评估和临床决策，使用适当的促甲状腺激素（TSH）、游离甲状腺素（fT4）和游离三碘甲状腺原氨酸（fT3）参考区间至关重要。建议每个实验室建立自己的参考区间。为了首次对斯洛文尼亚的甲状腺激素参考区间进行评估，回顾性地确定了一个由 1722 名无甲状腺疾病的健康个体组成的大组。激素分析在自动化分析仪 Advia Centaur XP 免疫测定系统（西门子健康公司）上进行，该系统的 TSH、fT4 和 fT3 的参考区间分别为 0.55-4.78 mIU/L、11.5-22.7 pmol/L 和 3.5-6.5 pmol/L。统计分析遵循非参数百分位法。我们实验室的 TSH、fT4 和 fT3 的参考区间大多比制造商提供的区间窄。TSH、fT4 和 fT3 的中位数、下限和上限值分别为 1.98（0.59-4.23）mIU/L、14.5（11.3-18.8）pmol/L 和 4.82（3.79-6.05）pmol/L。很可能，纳入大量无甲状腺疾病的健康个体是导致这种结果的原因。
