Rascovsky Katya, Salmon David P, Hansen Lawrence A, Thal Leon J, Galasko Douglas
Department of Neurosciences, University of California, San Diego, CA, USA.
Neuropsychology. 2007 Jan;21(1):20-30. doi: 10.1037/0894-4105.21.1.20.
Patients with autopsy-confirmed frontotemporal dementia (FTD; n = 16) and Alzheimer's disease (AD; n = 32) were compared on first-letter and semantic category fluency tasks. Despite being matched on age, education, and dementia severity, FTD patients performed worse overall and showed similar impairment in letter and semantic category fluency, whereas AD patients showed greater impairment in semantic category than letter fluency. A measure of the disparity between letter and semantic category fluency (the semantic index) was effective in differentiating FTD from AD patients, and this disparity increased with increasing severity of dementia. These unique patterns of letter and semantic category fluency deficits may be indicative of differences in the relative contribution of frontal-lobe-mediated retrieval deficits and temporal-lobe-mediated semantic deficits in FTD and AD.
对经尸检确诊的额颞叶痴呆（FTD；n = 16）患者和阿尔茨海默病（AD；n = 32）患者进行了首字母流畅性和语义类别流畅性任务的比较。尽管在年龄、教育程度和痴呆严重程度上进行了匹配，但FTD患者总体表现更差，在字母流畅性和语义类别流畅性方面表现出相似的损伤，而AD患者在语义类别流畅性方面的损伤比字母流畅性更大。一种衡量字母流畅性和语义类别流畅性之间差异的指标（语义指数）在区分FTD患者和AD患者方面是有效的，并且这种差异随着痴呆严重程度的增加而增大。字母流畅性和语义类别流畅性缺陷的这些独特模式可能表明额叶介导的检索缺陷和颞叶介导的语义缺陷在FTD和AD中的相对贡献存在差异。
