Lonie Jane A, Herrmann Lucie L, Tierney Kevin M, Donaghey Claire, O'Carroll Ronan, Lee Andrew, Ebmeier Klaus P
Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
J Neuropsychol. 2009 Mar;3(Pt 1):79-92. doi: 10.1348/174866408X289935.
Episodic memory is compromised in amnestic mild cognitive impairment (aMCI), but lesser deficits in other cognitive domains are also commonly observed and may be helpful in identifying this group. The relative difference in performance on lexical and semantic fluency tasks may be a sensitive and specific measure in aMCI and early Alzheimer's disease (AD). We compared four groups of participants, 35 early AD, 47 aMCI, 24 healthy controls, and 18 depressive out-patient controls, on semantic and lexical fluency as well as other neuropsychological tests. Early AD and aMCI patients showed a distinct pattern of semantic impairment in the two fluency measures compared with the healthy and depressive controls. The findings implicate early failure of the semantic memory system in aMCI and AD and suggest that consideration of the discrepancy in performance on semantic and lexical fluency measures may help in the early identification of AD.
情景记忆在遗忘型轻度认知障碍（aMCI）中受损，但在其他认知领域也常观察到较小的缺陷，这些缺陷可能有助于识别该群体。词汇和语义流畅性任务表现的相对差异可能是aMCI和早期阿尔茨海默病（AD）的一种敏感且特异的测量方法。我们比较了四组参与者，35名早期AD患者、47名aMCI患者、24名健康对照者和18名抑郁门诊对照者，进行语义和词汇流畅性以及其他神经心理学测试。与健康对照者和抑郁对照者相比，早期AD患者和aMCI患者在两种流畅性测量中表现出明显的语义损伤模式。这些发现表明语义记忆系统在aMCI和AD中早期就出现功能障碍，并提示考虑语义和词汇流畅性测量表现的差异可能有助于AD的早期识别。
