Schretlen David J, Inscore Anjeli B, Jinnah H A, Rao Vani, Gordon Barry, Pearlson Godfrey D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287-7218, USA.
Neuropsychology. 2007 Jan;21(1):136-40. doi: 10.1037/0894-4105.21.1.136.
Among possible markers of age-related cognitive decline, uric acid (UA) is controversial because it has antioxidant properties but is increased in diseases that often lead to cognitive impairment. In this study of 96 elderly adults, participants with mildly elevated (but normal) serum UA were 2.7 to 5.9 times more likely to score in the lowest quartile of the sample on measures of processing speed, verbal memory, and working memory. Even after controlling for age, sex, race, education, diabetes, hypertension, smoking, and alcohol abuse, the multivariate-adjusted odds of poor verbal memory and working memory remained significant (ps < .05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults.
在与年龄相关的认知衰退的可能标志物中，尿酸（UA）存在争议，因为它具有抗氧化特性，但在经常导致认知障碍的疾病中会升高。在这项针对96名老年人的研究中，血清尿酸轻度升高（但仍正常）的参与者在处理速度、言语记忆和工作记忆测量中得分处于样本最低四分位数的可能性要高出2.7至5.9倍。即使在控制了年龄、性别、种族、教育程度、糖尿病、高血压、吸烟和酗酒等因素后，言语记忆和工作记忆不佳的多变量调整后优势仍然显著（p值<0.05）。尽管尿酸具有抗氧化特性，但这些发现表明，即使是尿酸的轻度升高也可能增加老年人认知衰退的风险。
