成年人的睡眠质量和睡眠时间与血清尿酸水平的关系。
Association of sleep quality and sleep duration with serum uric acid levels in adults.
机构信息
Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Department of Health Management Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
PLoS One. 2020 Sep 17;15(9):e0239185. doi: 10.1371/journal.pone.0239185. eCollection 2020.
OBJECTIVE
To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population.
METHODS
A total of 4,555 patients aged ≥18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7-9 h), and long (≥9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5.
RESULTS
Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels.
CONCLUSIONS
Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.
目的
截至目前，关于睡眠时间或睡眠质量与高尿酸血症之间的关联仍不明确。此外，在以往的研究中，并未同时考虑睡眠时间和质量。因此，本研究旨在探讨在台湾人群中，睡眠时间和睡眠质量与尿酸水平之间的关系。
方法
共纳入 4555 名年龄≥18 岁的患者。睡眠时间分为三组：短（<7 h）、正常（7-9 h）和长（≥9 h）。采用匹兹堡睡眠质量指数（PSQI）评估睡眠质量，PSQI 总分>5 分定义为睡眠质量差。
结果
与睡眠良好者相比，睡眠质量差者的年龄较小，体重指数、血压、尿酸、血糖、胆固醇、肌酐水平较低，睡眠时间较短，运动较少，但白细胞计数较高，吸烟率较高。不同睡眠时间的患者之间还存在体重指数、血压、尿酸、血糖、血脂谱和睡眠质量的差异。在调整其他变量后，睡眠质量差与尿酸水平降低有关。此外，睡眠时间短与尿酸水平升高有关。
结论
睡眠质量差与尿酸水平降低有关，而睡眠时间短与尿酸水平升高有关。
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