Frankel Fred, Paley Blair, Marquardt Renee, O'Connor Mary
UCLA School of Medicine, Los Angeles, California, USA.
J Child Adolesc Psychopharmacol. 2006 Dec;16(6):777-89. doi: 10.1089/cap.2006.16.777.
Peer relationship problems are a significant part of the clinical presentation of children with Fetal Alcohol Spectrum Disorders (FASD). Many of these children have been prescribed psychotropic medications by community practitioners. The present study reports on the interaction between medication status and parent and teacher-reported outcomes for parent-assisted Children's Friendship Training (CFT).
Seventy seven children (40 boys and 37 girls, age range was 71-139 months) diagnosed with FASD were given 12 sessions of CFT. Parent- and teacher-reported social outcomes were compared across four subgroups of children who were prescribed either stimulant or neuroleptic medication, neither or both types of medications.
According to parent and teacher reports, children prescribed neuroleptic medication showed greater improvement on all outcome measures when compared to children not prescribed neuroleptics. In contrast, children prescribed stimulant medication either failed to show improvement or showed poorer outcomes when compared to children not prescribed stimulants.
Children with FASD frequently present with symptoms of inattention and hyperactivity. The present results suggest physicians routinely ask about prenatal alcohol exposure as part of history taking to treat children more effectively who appear to be displaying attention-deficit/hyperactivity disorder symptomatology but who may have FASD.
同伴关系问题是胎儿酒精谱系障碍（FASD）儿童临床表现的重要组成部分。许多这类儿童已由社区医生开具精神药物处方。本研究报告了药物使用状况与家长及教师报告的家长辅助儿童友谊训练（CFT）结果之间的相互作用。
77名被诊断为FASD的儿童（40名男孩和37名女孩，年龄范围为71 - 139个月）接受了12次CFT训练。对分别开具了兴奋剂或抗精神病药物、未开具任何一种药物或同时开具了两种药物的四个儿童亚组，比较家长和教师报告的社交结果。
根据家长和教师的报告，与未开具抗精神病药物的儿童相比，开具了抗精神病药物的儿童在所有结果指标上都有更大改善。相比之下，与未开具兴奋剂的儿童相比，开具了兴奋剂药物的儿童要么没有表现出改善，要么表现出更差的结果。
FASD儿童经常出现注意力不集中和多动症状。目前的结果表明，医生在问诊时应常规询问产前酒精暴露情况，作为病史采集的一部分，以便更有效地治疗那些似乎表现出注意力缺陷/多动障碍症状但可能患有FASD的儿童。
