相界与生物膜
Phase boundaries and biological membranes.
作者信息
Feigenson Gerald W
机构信息
Field of Biophysics, Cornell University, Ithaca, New York 14853, USA.
出版信息
Annu Rev Biophys Biomol Struct. 2007;36:63-77. doi: 10.1146/annurev.biophys.36.040306.132721.
Abstract
Bilayer mixtures of lipids are used by many researchers as chemically simple models for biological membranes. In particular, observations on three-component bilayer mixtures containing cholesterol show rich phase behavior, including several regions of two-phase coexistence and one region of three-phase coexistence. Yet, the relationship between these simple model mixtures and biological membranes, which contain hundreds of different proteins and lipids, is not clear. Many of the model mixtures have been chosen for study because they exhibit readily observed phase separations, not because they are good mimics of cell membrane components. If the many components of cell membranes could be grouped in some way, then understanding the phase behaviors of biological membranes might be enhanced. Furthermore, if the underlying interaction energies between lipids and proteins can be determined, then it might be possible to model the distributions of lipids and proteins in a bilayer membrane, even in complex mixtures.
摘要
许多研究人员将脂质双层混合物用作生物膜的化学简单模型。特别是，对含有胆固醇的三元双层混合物的观察显示出丰富的相行为，包括几个两相共存区域和一个三相共存区域。然而，这些简单的模型混合物与包含数百种不同蛋白质和脂质的生物膜之间的关系尚不清楚。许多模型混合物被选作研究对象是因为它们表现出易于观察到的相分离，而不是因为它们是细胞膜成分的良好模拟物。如果细胞膜的许多成分能够以某种方式进行分组，那么对生物膜相行为的理解可能会得到加强。此外，如果能够确定脂质和蛋白质之间潜在的相互作用能，那么即使在复杂混合物中，也有可能对双层膜中脂质和蛋白质的分布进行建模。
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