细胞凋亡与炎症细胞内信号传导中的死亡结构域超家族
The death domain superfamily in intracellular signaling of apoptosis and inflammation.
作者信息
Park Hyun Ho, Lo Yu-Chih, Lin Su-Chang, Wang Liwei, Yang Jin Kuk, Wu Hao
机构信息
Department of Biochemistry, Weill Medical College and Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA.
出版信息
Annu Rev Immunol. 2007;25:561-86. doi: 10.1146/annurev.immunol.25.022106.141656.
Abstract
The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.
摘要
死亡结构域（DD）超家族由死亡结构域（DD）亚家族、死亡效应结构域（DED）亚家族、半胱天冬酶招募结构域（CARD）亚家族和吡啉结构域（PYD）亚家族组成，是最大的结构域超家族之一。通过介导每个结构域亚家族内的同型相互作用，这些蛋白质在凋亡和炎症复合物的组装及激活中发挥重要作用。在本章中，我们综述了由这些蛋白质组装而成的分子复合物、这些结构域的结构和生化特征以及它们介导的分子相互作用。通过分析这些结构域功能的潜在分子基础，我们希望能全面了解这个重要结构域家族的功能、结构、相互作用及进化。
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