Nagase M, Chen R B, Araya Y, Nakajima T
First Department of Oral and Maxillofacial Surgery, School of Dentistry, Niigata University, Japan.
J Oral Maxillofac Surg. 1991 Dec;49(12):1305-9. doi: 10.1016/0278-2391(91)90309-a.
Tissue response to a readily consolidating material prepared by mixing alpha-tricalcium phosphate (alpha-TCP) powder with a glycolic acid dextran solution and to this consolidating material combined with particulate hydroxylapatite (HA) was studied after implantation in the subperiosteal space of the mandible in rabbits. Active new bone formation comparable to that seen on HA implants was observed around the two compounds. The newly formed bone was in direct contact with the HA as well as the readily consolidated material and little adverse effect resulting from the glycolic acid and dextran was observed. Because the readily consolidating material was firm and could be contoured into any shape during the process of consolidation, it may be quite useful as a bone substitute and as an adherent for HA particles for reconstructive bone surgery, overcoming the disadvantages inherent to the particulate form of HA.
研究了将α-磷酸三钙（α-TCP）粉末与乙醇酸葡聚糖溶液混合制备的易固化材料，以及该固化材料与颗粒状羟基磷灰石（HA）结合后，植入兔下颌骨骨膜下间隙的组织反应。在这两种化合物周围均观察到与HA植入物上所见相当的活跃新骨形成。新形成的骨与HA以及易固化材料直接接触，且未观察到乙醇酸和葡聚糖产生的不良影响。由于易固化材料质地坚硬，在固化过程中可塑造成任何形状，因此作为骨替代物以及用于重建骨手术的HA颗粒黏附剂可能非常有用，克服了HA颗粒形式固有的缺点。
