Mehlisch D R, Leider A S, Roberts W E
Biomedical Research Group, Inc., Austin.
Oral Surg Oral Med Oral Pathol. 1990 Dec;70(6):685-92. doi: 10.1016/0030-4220(90)90001-9.
Samples of the bone/graft interface were evaluated histologically in five patients 1 year after mandibular ridge augmentation with a composite of hydroxylapatite particles in a matrix of purified fibrillar collagen (HA/PFC). The resulting defects were refilled with HA/PFC after the biopsy specimens were obtained. Histologic examination of the specimens yielded no evidence of purified fibrillar collagen. Hydroxylapatite particles were surrounded by dense fibrous host connective tissue, trabeculae of woven and lamellar bone, or both. HA/PFC was found to be biocompatible with human tissue and receptive to direct bone apposition on the hydroxylapatite particles.
对5例患者在下颌牙槽嵴用纯化纤维状胶原基质中的羟基磷灰石颗粒复合物（HA/PFC）进行增高术后1年的骨/移植物界面样本进行组织学评估。获取活检标本后，用HA/PFC填充产生的缺损。标本的组织学检查未发现纯化纤维状胶原的证据。羟基磷灰石颗粒被致密的纤维性宿主结缔组织、编织骨和板层骨小梁或两者包围。发现HA/PFC与人体组织具有生物相容性，并易于羟基磷灰石颗粒上直接的骨附着。
